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20-Oct-2019 06:31 by 6 Comments

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The obstacles social determinants of health can pose to low-income city residents amplify the detrimental impact of ACA repeal on the health of cities.

There is substantially less evidence on cancer risk associated with these preparations than there is on cancer risk associated with the oral contraceptive pill.With steady success during the remainder of the 1960s (both as a solo artist and with a series of duet albums with Porter Wagoner), her sales and chart peak came during the 1970s and continuing into the 1980s; Parton's subsequent albums in the later part of the 1990s were lower in sales.However, in the new millennium, Parton achieved commercial success again and has released albums on independent labels since 2000, including albums on her own label, Dolly Records.Background: Inconsistent associations have been reported between diet and breast cancer.Objective: We prospectively examined the association between dietary patterns and postmenopausal breast cancer risk in a US-wide cohort study.Design: Data were analyzed from 40 559 women who completed a self-administered 61-item Block food-frequency questionnaire in the Breast Cancer Detection Demonstration Project, 1987–1998; 1868 of those women developed breast cancer.

Dietary patterns were defined by using principal components factor analysis.1 on the Billboard country music charts, a record for a female artist (tied with Reba Mc Entire).She has 41 career top 10 country albums, a record for any artist, and she has 110 career charted singles over the past 40 years.In post-menopausal women, breast cancer risk is around twice as high in those with the highest sex hormone levels (including oestradiol, oestriol, androstenedione and testosterone) compared with the lowest, a pooled analysis of cohort studies showed.[1] In pre-menopausal women, breast cancer risk is not significantly associated with oestrogen levels, a meta-analysis and the EPIC cohort study have shown.[1,2] Pre-menopausal breast cancer risk is 56% higher in those with the highest serum testosterone levels compared with the lowest, whilst other sex hormones show no clear association, EPIC showed.[2] Some reproductive factors modify sex hormone levels; reduction in overall oestrogen exposure may partly explain the link between reproductive factors and breast cancer risk.Breastfeeding is classified by the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) as probably protective against breast cancer.[1] Breast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed.[1] The association may be limited to ER/PR-positive tumours.[2-4] ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed.[4] HER2-positive and triple-negative breast cancers are not associated with age at first birth.[4] Conversely among BRCA1 mutation carriers, breast cancer risk may be lower in those who are older at first birth, meta-analyses have shown;[5,6] among BRCA2 carriers, breast cancer risk is not associated with age at first birth.[5,6] Breast cancer risk increases by 5% for each year younger at menarche (first menstrual period), a meta-analysis has shown.[1] The association is stronger for oestrogen receptor (ER)-positive and progesterone receptor (PR)-positive tumours than for ER- and PR-negative tumours.[2] Breast cancer risk may be higher in women whose breast development started at a younger age, a cohort study indicates.[3] Among BRCA1 mutation carriers too, breast cancer risk may be higher in those who are younger at menarche, a meta-analysis showed; among BRCA2 carriers, breast cancer risk is not associated with age at menarche.[4,5] Breast cancer risk increases by around 3% for each year older at menopause, a meta-analysis has shown.[1] Post-menopausal women (natural menopause or induced by surgery) have a lower risk of breast cancer than pre-menopausal women of the same age and childbearing pattern, a meta-analysis showed.[1] Breast cancer risk is not associated with tubal sterilisation, a meta-analysis showed.[1] Breast cancer risk is 24-41% lower in women who have hysterectomy and oophorectomy before menopause, compared with women who do not have these surgeries, a pooled analysis and case-control study showed.[2,3] Hysterectomy and oophorectomy after menopause may be associated with increased breast cancer risk if oestrogen therapy is used after the surgery, a pooled analysis showed.[2] Current or recent use of combined oestrogen-progestogen oral contraceptives (OCs) is classified by the International Agency for Research on Cancer (IARC) as a cause of breast cancer.[1] An estimated 1% of female breast cancers in the UK are linked to OCs; because breast cancer risk is generally low in the OC-using population (typically younger women), OC-related risk contributes a relatively small number of additional cases.[2] OCs contain synthetic sex hormones, which may explain the link between OC use and breast cancer risk.Absent such essentials, good health can be difficult to maintain, what with the rising cost of care in the U. and uneven standards for health education in public schools.

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